Publications

  • CD47 blockade triggers T cell-mediated destruction of Immunogenic tumors. Liu, X., Pu, Y., Cron, K., Deng, L., Kline, J., Frazier, W.A., Xu, H., Peng, H., Fu, Y.X. and Xu, M.M. Nat Med 21:1209-1215 (2015). [abstract]
  • Phosphorylation of the BNIP3 C-terminus inhibits mitochondrial damage and cell death without blocking autophagy. Liu, K.E. and Frazier, W.A. PLoS One 10:e0129667 (2015). [abstract]
  • Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma. Xiao, Z.Y., Chung, H., Banan, B., Manning, P.T., Ott, K.C., Lin, S., Capoccia, B.J., Subramanian, V., Hiebsch, R.R., Upadhya, G., Mohanakumar, T., Frazier, W.A., Lin, Y. and Chapman, W.C. Cancer Lett. 360:302-309 (2015). [abstract]
  • CD47 blockade reduces ischemia reperfusion injury and improves survival in a rat liver transplantation model. Xiao, Z.Y., Banan, B., Jia, J., Manning, P.T., Hiebsch, R.R., Gunasekaran, M., Upadhya, G., Frazier, W.A., Mohanakumar, T., Lin, Y. and Chapman, W.C. Liver Transplantation 21:468-477 (2015). [abstract]
  • Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts. Amend, S.R., Uluckan, ). Hurchla, M., Leib, D., Novack D.V., Silva, M., Frazier, W. and Weilbaecher, K.N. J Bone Miner Res 30:106-115 (2015). [abstract]
  • CD47 blockade reduces ischemia-reperfusion injury and improves outcomes in a rat kidney transplant model. Lin, Y., Manning, P.T., Jia, J., Gaut, J.P., Xiao, Z., Capoccia, B.J., Chen, C.C., Hiebsch, R.R, Upadhya, G., Mohanakumar, T., Frazier, W.A. and Chapman, W.C. Transplantation 98:394-401 (2014). [abstract]
  • Imaging of CD47 Expression in Xenograft and Allograft Tumor Models. Zheleznyak, A., Ikotun, O.F., Dimitry, J., Frazier, W.A. and Lapi, S.E. Mol Imaging 12(8). doi: 10.2310/7290.2013.00069 (2013). [abstract]
  • CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions. Azcutia, V., Routledge, M., Williams, M.R., Newton, G., Frazier, W.A., Manica, A., Croce, K.J., Parkos, C.A., Schmider, A.B., Turman, M.V., Soberman, R.J. and Luscinskas, F.W. Mol Biol Cell 24:3358-3368 (2013).[abstract]
  • Inhibitory signaling through signal regulatory protein-alpha is not sufficient to explain the antitumor activities of CD47 antibodies. Soto-Pantoja, D.R., Miller, T.W., Frazier, W.A. and Roberts, D.D. PNAS 109:E2842 (2012).  [pdf]
  • Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. Frazier, E.P., Isenberg, J.S., Shiva, S., Zhao, L., Schlesinger, P., Dimitry, J., Abu-Asab, M.S., Tsokos, M., Roberts, D.D. and Frazier, W.A. Matrix Biology 30:154-161 (2011).  [pdf]
  • CD36 ligands promote sterile inflammation through assembly of a toll-like receptor 4 and 6 heterodimer. Stewart, C.R., Stuart, L.M., Wilkinson, K., van Gils, J.M., Deng, J., Halle, A., Rayner, K.J., Boyer, L., Zhong, R., Frazier, W.A., Lacy-Hulbert, A., Khoury, J.E. Golenbock, D.T. and Moore, K.J. Nat Immunol 11:155-161 (2010).  [pdf]
  • Decreased CD47 expression during spontaneous apoptosis targets neutrophils for phagocytosis by monocyte-derived macrophges. Lawrence, D.W., King, S.B., Frazier, W.A. and Koenig, J.M. Early Hum Dev. 85:659-663 (2009).  [pdf]
  • Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. Isenberg, J.S., Qin, Y., Maxhimer, J.B., Sipes, J.M., Despres, D., Schnermann, J., Frazier, W.A. and Roberts, D.D. Matrix Biology 28:110-119 (2009).  [pdf]
  • CD47 regulates bone mass and tumor metastasis to bone. Uluçkan, O., Becker, S.N., Deng, H., Zou, W., Prior, J.L., Piwnica-Worms, D., Frazier, W.A. and Weilbaecher, K.N. Cancer Res 69:3196-3204 (2009).  [pdf]
  • Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Kohyama, M., Ise, W., Edelson, B.T., Wilker, P.R., Hildner, K., Mejia, C., Frazier, W.A., Murphy, T.L. and Murphy, K.M. Nature 457:318-321 (2009). [pdf]
  • Differential interactions of thrombospondins-1, -2 and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. Isenberg, J.S., Annis, D.S., Pendrak, M.L., Ptaszynska, M., Frazier, W.A., Mosher, D.F. and Roberts, D.D. J Biol Chem 284:1116-1125 (2009). [pdf]
  • Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling. Isenberg, J.S. Maxhimer, J.B., Powers, P., Tsokos, M., Frazier, W.A. and Robert, D.D. Surgery 144:752-761 (2008).  [pdf]
  • Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. Isenberg, J.S., Frazier, W.A., Krishna, M.C., Wink, D.A. and Roberts, D.D. Curr Drug Targets 9:833-841 (2008). [abstract]
  • A naturally occurring extracellular alpha-beta clasp contributes to stabilization of beta3 Integrins in a bent, resting conformation. Vomund, A.N., Stuhlsatz-Krouper, S., Dimitry, J., Song, Y. and Frazier, W.A. Biochemistry 47:11616-11624 (2008). [pdf]
  • Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Isenberg, J.S., Romeo, M.J, Yu, C., Yu, C.K., Nghiem, K., Monsale, J., Rick, M.E., Wink, D.A., Frazier, W.A. and Roberts, D.D. Blood 111:613-623 (2008).  [pdf]
  • CD47. A new target in cardiovascular therapy. Isenberg, J.S., Roberts, D.D. and Frazier, W.A. Arterioscler Thromb Vasc Biol. 28:615-621 (2008).  [pdf]
  • Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts. Isenberg, J.S., Isenberg, J.S., Pappan, L.K., Romeo, M.J., Abu-Asab, M., Tsokos, M., Wink, D.A., Frazier, W.A. and Roberts, D.D. Ann Surg. 247:180-190 (2008). [pdf]
  • Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia. Isenberg, J.S., Hyodo, F., Pappan, L.K., Abu-Asab, M., Tsokos, M., Krishna, M.C., Frazier, W.A. and Roberts, D.D. Arterioscler Thromb Vasc Biol 27:2582-2588 (2007). [pdf]
  • Thrombospondin-1 stimulates platelet aggregation by blocking the anti-thrombotic activity of nitric oxide/cGMP signaling. Isenberg, J.S., Romeo, M.J., Yu, C., Yu, C.K., Nghiem, K., Monsale, J., Rick, M.E., Wink, D.A., Frazier, W.A. and Roberts, D.D. Blood 109:1945-1952 (2007). [pdf]
  • Increasing survival of ischemic tissue by targeting CD47. Isenberg, J.S., Romeo, M.J., Abu-Asab, M., Tsokos, M., Oldenborg, A., Pappan, L., Wink, D.A., Frazier, W.A. and Roberts, D.D. Circ. Res. 100:712-720 (2007). [pdf]
  • CD47 necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1. Isenberg, J.S., Ritnour, L.A., Dimitry, J., Frazier, W.A., Wink, D.A. and Roberts, D.D. J Biol Chem 281:26069-26080 (2006). [pdf]
  • Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration. Hagnerud, S., Manna, P.P., Cella, M., Stenberg, A., Frazier, W.A. and Oldenborg, P.A. J Immunol 176:5772-5778 (2006). [pdf]
  • CD47 augments Fas/CD95-mediated apoptosis. Manna, P.P., Dimitry, J., Oldenborg, P.A. and Frazier, W.A. J Biol Chem 280:29637-29644, 2005. [pdf]
  • Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor. Isenburg, J.S., Calzada, M.J., Zhou, L., Guo, N., Lawler, J., Wang, X.Q., Frazier, W.A. and Roberts, D.D. Matrix Biology 44:110-123, 2005. [pdf]
  • Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Olsson, M., Bruhns, P., Frazier, W.A., Ravetch, J.V. and Oldenborg, P.A. Blood 105:3577-3582, 2005.[pdf]
  • Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity. McDonald, J.F., Zheleznyak, A. and Frazier, W.A. J Biol Chem 279:17301-17311, 2004. [pdf]
  • CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A. Manna, P.P. and Frazier, W.A. Cancer Research 64:1026-1036, 2004.[pdf]
  • An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs. McDonald, J.F., Dimitry, J.M. and Frazier, W.A.Biochemistry 42:10001-10011, 2003. [pdf]
  • The mechanism of CD47-dependent killing of T cells: Heterotrimeric G(i)-dependent inhibition of protein kinase A. Manna, PP. and Frazier, W.A. Journal of Immunology 170:3544-3553, 2003. [pdf]
  • Integrin-associated protein (CD47) and its ligands. Brown, E. J. and Frazier, W. A.Trends in Cell Biology 11:130-135, 2001. [pdf]
  • Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte generated reactive nitrogen species. Podrez, E. A., Febbraio, M., Sheibani, N., Schmitt, D., Silverstein, R.L. Hajjar, D.P., Cohen, P.A., Frazier, W.A., Hoff, H.F. and Hazen, S.L. J. Clin. Invest. 105:1095-1108, 2000. [pdf]
  • Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases. Sheibani, N., Sorenson, C. M. and Frazier, W.A. Mol. Biol. Cell 11:2793-2802, 2000. [pdf]
  • Thrombospondin-1, A natural inhibitor of angiogenesis, is present in Vitreous and Aqueous Humor and is Modulated by hyperglycemia. Sheibani, N., Sorenson, C. M., Cornelius, L. A. and Frazier, W. A. Biochem. Biophys. Res. Commun, 267:257-261, 2000. [pdf]
  • CD47, a Ligand for the Macrophage Fusion Receptor, Participates in Macrophage Multinucleation. Han, X., Sterling, H., Chen, Y., Saginario, C., Brown, E.J., Frazier, W. A., Lindberg, F. P. and Vignery, A. J. Biol. Chem. 275: 37984-37992, 2000. [pdf]
  • The Thrombospondin Receptor Integrin-Associated Protein (CD47) Functionally Couples to Heterotrimeric Gi. Frazier, W.A., Gao, A-G., Dimitry, J., Chung, J., Brown, E.J., Lindberg, F.P. and Linder, M.E., J. Biol. Chem. 274: 8554-8560, 1999. [pdf]
  • Thrombospondin-1 Acts via IAP/CD47 to Synergize with Collagen in alpha2beta1 mediated Platelet Activation. Chung, J., Wang, X-Q., Lindberg, F.P. and Frazier, W.A. Blood 94: 642-648, 1999. [pdf]
  • Tissue-specific Expression of Alternatively Spliced Murine PECAM-1 Isoforms. Sheibani, N., Sorenson, C.M. and Frazier,W.A. Developmental Dynamics 214:44-54, 1999. [pdf]
  • Thrombospondin-1, PECAM-1 and Regulation of Angiogenesis. Sheibani, N. and Frazier, W.A. Histology and Histopathology 14:285-294, 1999.
  • Down-Regulation of Platelet Endothelial Cell Adhesion Molecule-1 Results in Thrombospondin-1 Expression and Concerted Regulation of Endothelial Cell Phenotype. Sheibani, N. and Frazier, W.A. Mol. Biol. of the Cell, 9:701-713, 1998. [pdf]
  • The Thrombospondin Receptor CD47 (IAP) Modulates and Associates with alpha2beta1 Integrin in Vascular Smooth Muscle Cells, Wang, X-Q. and Frazier, W.A. Mol. Biol. of the Cell, 9:865-874, 1998. [pdf]
  • CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells, Dawson, D.W. Pearce, F.A., Zhong, R., Silverstein, R.L., Frazier, W.A. and Bouck, N.P. J Cell Biol. 138:707-717, 1997. [pdf]
  • Thrombospondin Acts via Integrin-associated Protein to Activate the Platelet Integrin alphaIIbbeta3, Chung, J., Gao, A-G. and Frazier, W.A. J. Biol. Chem. 272:14740-14746, 1997. [pdf]
  • Thrombospondin-1, a Natural Inhibitor of Angiogenesis, Regulates Platelet-Endothelial Cell Adhesion Molecule-1 Expression and Endothelial Cell Morphogenesis. Sheibani, N., Newman, P.J. and Frazier,W.A. Mol Biol of the Cell, 8:1329-1341, 1997.
  • Thrombospondin Modulates avb3 Function Through Integrin-associated Protein, Gao, A-G., Lindberg, F.P., Dimitry, J.M., Brown, E.J. and Frazier, W.A. J. Cell Biol. 135: 533-544, 1996. [pdf]
  • Integrin-associated Protein is a Receptor for the C-terminal Domain of Thrombospondin. Gao, A-G., Lindberg, F.P., Finn, M.B., Blystone, S.D., Brown, E.J. and Frazier, W.A.  J. Biol. Chem. 271:21-24, 1996. [pdf]
  • pH-Dependent Self-association of the Src Homology 2 (SH2)domain of the Src Homologous and collagen-like (SHC) Protein. Rety, S., Futterer, K., Grucza, R.A., Munoz, C.M., Frazier, W.A. and Waksman, G.  Protein Science 5:405-413, 1996.
  • Thrombospondin 1 Expression in Transformed Endothelial Cells Restores a Normal Phenotype and Suppresses Their Tumorigenesis, Sheibani, N. and Frazier, W.A. PNAS, 92:6788-6792, 1995. [pdf]
  • Transfection of Thrombospondin 1 cDNA into a Human Breast Carcinoma Cell Line Reduces Primary Tumor Growth, Metastatic Potential and Angiogenesis. Weinstat-Saslow, D.L., Zabrenetzky, V.S., VanHoutte, K., Frazier, W.A., Roberts, D.D. and Steeg, P.S. Cancer Research 54:6504-6511, 1994.
  • Peptides Derived from Two Separate Domains of the Matrix Protein Thrombospondin-1 Have Anti-angiogenic Activity. Tolsma, S.S., Volpert, O.V., Good, D.J., Frazier, W.A., Polverini, P.J. and Bouck, N. J. Cell Biol. 122:497-511,1993. [pdf]
  • Identification of a New Cell Adhesion Motif in Two Homologous Peptides from the COOH-terminal Cell Binding Domain of Human Thrombospondin. Kosfeld, M. and Frazier, W.A.  J. Biol. Chem. 268:8808-8814, 1993. [pdf]